As more information is discovered about the role of Vitamin D, the benefits of supplementation become more and more apparent.
Vitamin D deficiency is associated with cardiovascular disease, cancer, autoimmune disorders such as Type 1 Diabetes, Multiple Sclerosis, and inflammatory bowel disease.
Combining Vitamin K2 with D3 will give better absorption to help promote even better health.
Take one capsule daily, preferably at mealtime, or as directed by your healthcare practitioner.
Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Consider total vitamin K intake (food + supplements) if you are taking blood-thinning medication. Do not use if tamper seal is damaged.
There are only three methods to get Vitamin D into your system.
Because of the limited availability of food sources containing Vitamin D and the low amount of sun exposure most people get, supplementation may be the best way to increase serum levels of Vitamin D.
K2-D3 5000 features the most bioavailable and bioactive form of supplemental vitamin K2 available and vitamin D3 (cholecalciferol), the identical form in which vitamin D is derived in the body from cholesterol and synthesized by sunlight on the skin. Studies confirm safety and efficacy for bone and heart health.*
Vitamin D (as D3)
Although vitamin D3 (cholecalciferol) is made in the skin when
7-dehydrocholesterol reacts with sunlight, many things affect the degree to
which this biosynthesis occurs, including time of day, seasons, location, smog/
pollution, clothing, shade of skin (darker skin requires more sun), and sunscreen
use. Low-cholesterol diets and certain cholesterol therapies can also affect vitamin
D formation. By some estimates, one billion people worldwide have vitamin D
deficiency or insufficiency. The body needs vitamin D to absorb calcium, and the
importance of vitamin D in skeletal health and bone density is well-established.
Without adequate absorption, the body must take calcium from its stores in the
skeleton, which weakens existing bone and prevents the formation of strong,
new bone. Researchers suggest that vitamin D supplementation may decrease
bone turnover and increase bone mineral density. A pooled analysis evaluating
11 randomized, double-blind, placebo-controlled trials supported this analysis.
It concluded that vitamin D supplementation (> 800 IU daily) was favorable
in maintaining hip and nonvertebral bone integrity in individuals aged 65 and
Among the dietary factors critical to bone health, vitamin K has emerged as a key
player. Vitamin K is believed to be necessary for bone mineralization. Through
carboxylation, vitamin K activates osteocalcin, the protein needed to bind calcium
to the mineral matrix in bone. Several studies have demonstrated the efficacy
of MK-7 (e.g., doses of 45-90 mcg/d) to increase osteocalcin carboxylation and
to increase the cOC:ucOC ratio. A high cOC:ucOC ratio is associated with bone
health.[1,2,4] A recent in vitro study also showed an osteogenic effect of MK-7
administration on human mesenchymal cell differentiation. In addition, the
vitamin may protect bone integrity by reducing the synthesis of prostaglandin E2
or interleukin-6 by osteoclasts. Animal and human studies have demonstrated
a significant beneficial effect of MK-7 supplementation on bone health.[8-10]
Vitamin K and vitamin D share some similar characteristics and are believed to act
Cardiovascular and Other Health Benefits
Vitamin K benefits cardiovascular health by participating in the carboxylation of
matrix GLA protein (MGP), a protein regarded to be the most potent inhibitor of
arterial calcification. Researchers have demonstrated that supplementation with
vitamin K reduces arterial calcium deposits[1,3,12] and that long-term intake of
long-chain menaquinones is inversely correlated with calcium accumulation in
Vitamin K has specific receptor binding sites that allow it to regulate gene
activity. Besides its gene-mediating effects upon critical proteins, the vitamin
can also bind with the steroid and xenobiotic receptors and influence their
expression. In addition, vitamin K also demonstrates antioxidant activity;
reduces levels of certain markers, such as acute phase reactants (e.g., C-reactive
protein); and participates in the induction of apoptosis.*